Inuendo

Background for the Project

Populations and Methods

Expected Achievements

Contact and Partners

Research Network (protected)


	Population and Methods The research combines identical interview studies of couple fertility, biological studies of semen quality and neonatal studies of reproductive hormone profiles in Greenland, Sweden, Poland and Ukraine. Uniformed study design and centralised laboratory analyses allow for pooled epidemiologic analyses.The populations have been collected because of the documented and appropriate exposure contrast and the measures of fertility have been selected to pick up a range of effects, to distinguish male from female effects and prenatal from adult unset effects.
	See picture Some 2400 pregnant women are interviewed about their fertility and earlier pregnancies

	See picture Examination of apoptotic markers may provide clues of whether certain toxicants have effects on spermatogenesis

	See picture By the fluorescence in situ hybridisation technique we will determine the ratio between why Y or X chromosome bearing spermatozoa which may be disturbed by environmental chemicals

	See picture The Sperm Chromatin Structure Assay uses flow cytometry to detect anomalies in the sperm chromatin, which may have bearings as to fertility and foetal development